Cubs starter Gonzalez Germen could not pitch himself out of the first inning, as his first four batters reached safely. Frazier's bases-loaded single scored one run before bench candidate Brennan Boesch added a two-run ground-rule double to right field that extended his team lead with 12 RBIs. The inning's ninth batter, pinch-hitter Kristopher Negron, walked to force in a run and chase Germen.
"We just did some good things," Reds manager Bryan Price said. "I think we had 16 or 17 baserunners. Everyone was putting together good at-bats. I think strike-zone command, especially early in the counts, put us in some pretty good situations to hit."
Germen, who was sent to Minor League camp by Chicago earlier this week, finished with two-thirds of an inning and allowed four earned runs, four hits and three walks with two strikeouts.
Cincinnati used a cavalcade of relievers to pitch the game, including closer Aroldis Chapman as the starter. Chapman struck out the side in the top of the first inning for the win. Manny Parra followed with a scoreless second inning, and Tony Cingrani gave up two hits and a walk over his 1 2/3 innings with four strikeouts.
Nate Adcock, who is trying to earn a spot in the Reds' bullpen, gave up two runs and three hits in the Cubs' fifth inning. Arismendy Alcantara drove in the first run with a lined single to right field that scored Javier Baez. Dexter Fowler came home on a Jorge Soler RBI groundout to third base.
Fowler homered to lead off the seventh for the Cubs, and Junior Lake later followed with a two-run single for a three-run Chicago inning.
Boesch tied Frazier for the Reds' team lead in homers with a solo shot in the seventh, his fourth of the Cactus League season, to complete his three-RBI day.
Up next: Catcher Devin Mesoraco has hits in his last three games while going 4-for-12 and should be back behind the plate Sunday at 3:05 p.m. ET when the Reds meet the Angels in Tempe. Jason Marquis, who has a 3.15 ERA over his five starts, will be back to try and cement a rotation spot for Cincinnati. Also expected to pitch are J.J. Hoover and Pedro Villarreal. The game can be seen live on MLB.TV and listened to on Gameday Audio.
Mark Sheldon is a reporter for MLB.com. Read his blog, Mark My Word, and follow him on Twitter @m_sheldon. This story was not subject to the approval of Major League Baseball or its clubs.