Things did not go as smoothly for D-backs starter Yoan Lopez, who allowed five runs on five hits in three innings, striking out two against two walks.
The Brewers got on the board in the second inning when Elian Herrera doubled home Gerardo Parra, and they broke things open with a four-run third. All of the runs came after Lopez retired the first two batters.
Things really got ugly for the D-backs in the fifth as the Brewers sent 11 men to the plate and scored seven runs to go up, 12-0.
Brewers shortstop Jean Segura went 3-for-4 with a double and three RBIs, while Scooter Gennett went 2-for-4 with two RBIs and two runs scored.
A.J. Pollock, Ender Inciarte and Blake Lalli were the only D-backs starters with hits, recording one each.
Up next for the D-backs: The D-backs have their first day off of the spring Wednesday. They return to action Thursday with a 1:10 p.m. MST game against the Padres at Salt River Fields. Chase Anderson, who is battling to win a spot in the rotation, will start for the D-backs. Reliever Brad Ziegler is expected to make his second Cactus League appearance.
Steve Gilbert is a reporter for MLB.com. Read his blog, Inside the D-backs, and follow him on Twitter @SteveGilbertMLB. This story was not subject to the approval of Major League Baseball or its clubs.