Austin Jackson and Seth Smith each had two hits for the Mariners. Smith, who was traded from the Padres to the Mariners in December, had a home run in the third inning, his first of Spring Training.
Smith's home run came off Padres right-hander Andrew Cashner. Cashner allowed three runs in four innings. He walked two and struck out four and got stretched to 82 pitches.
"He threw with good velocity, and we saw some good pitches just off the corners," Padres manager Bud Black said. "Overall, I thought his stuff was good."
The Padres also got two hits from Will Middlebrooks.
Up next for the Padres: Left-hander Jason Lane gets the start on Wednesday (1:05 p.m. PT, MLB.TV) as the Padres hit the road for a Cactus League game in Glendale against the Dodgers at Camelback Ranch. Ian Kennedy would have gotten the start, but he'll pitch in a Minor League game instead. This decision was likely made because the Padres would rather Kennedy not face the division-rival Dodgers this late in spring, with the two teams facing each other 19 times in the regular season. Lane, likely ticketed for Triple-A El Paso, has a 4.70 ERA in four appearances.
Corey Brock is a reporter for MLB.com. Keep track of @FollowThePadres on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.