Pelfrey, battling for a spot in the Minnesota rotation, also surrendered an early run before settling down with three consecutive zeroes. He allowed three hits and struck out three without issuing a walk.
The Twins wasted little time grabbing the lead, as Shane Robinson drew a one-out walk in the first, stole second base and scored on Kennys Vargas' double to left field. Oswaldo Arcia then singled to left, but Vargas was held at third and was stranded there.
The Red Sox responded in the bottom of the frame, with Mookie Betts slashing his seventh extra-base hit of the spring to right field and coming home on Hanley Ramirez's missile off the Green Monster. Ramirez, who entered play 4-for-22 (.182) in the Grapefruit League, was thrown out by Arcia while trying for a double.
Jeff Bianchi pulled the Sox even in the eighth with an RBI single and then scored the go-ahead run on Matt Spring's single to right field.
Up next: Right-hander Ricky Nolasco is set to make his third start when the Twins travel to Port Charlotte to face the Rays on Thursday in a 12:05 p.m. CT game that will air on MLB.TV. Right-hander Alex Meyer, ranked as the No. 29 overall prospect by MLB.com, is also scheduled to see action. Other pitchers slated to throw include A.J. Achter and Tim Stauffer, who was recently moved to the bullpen.
Andrew Simon is a reporter for MLB.com. Follow him on Twitter @AndrewSimonMLB. This story was not subject to the approval of Major League Baseball or its clubs.