He outdueled Reds ace Johnny Cueto, who gave up two runs on the Denorfia homer -- his only hit allowed. He did walk three, and struck out one.
"It was a good day out there for the whole team, really," Wood said. "We put across a couple runs and I was able to keep the ball down and get some early strikes and some quick outs."
Dexter Fowler walked with two outs in the third, and Denorfia drove him in with his first homer on the spring, off a 2-1 delivery from Cueto. They were the only Cubs runners to advance past first base.
"That was the plan, throwing four innings, and I felt great," said Cueto of his outing.
Ivan De Jesus Jr. had a ground-rule double for an RBI for the Reds' only run.
Devin Mesoraco, returning from a concussion, singled and walked in the game. Marlon Byrd, Brandon Phillips and Brennan Boesch also had hits for the Reds.
Up Next: The Reds play the first of four consecutive games in Goodyear with Monday's contest against the defending World Series champion Giants. It will be left-hander Tony Cingrani on the mound for Cincinnati, making his third appearance of the spring and second start. He has allowed one earned run on five hits in five innings of work thus far. Catcher Devin Mesoraco, who returned Sunday from a concussion, is likely to get some time either behind the plate or at designated hitter as he tries to catch up on his spring at-bats after missing seven days.
Joey Nowak is a reporter for MLB.com. Follow him on Twitter at @joeynowak. This story was not subject to the approval of Major League Baseball or its clubs.