He outdueled Reds ace Johnny Cueto, who gave up two runs on the Denorfia homer -- his only hit allowed. He did walk three, and struck out one.
"It was a good day out there for the whole team, really," Wood said. "We put across a couple runs and I was able to keep the ball down and get some early strikes and some quick outs."
Dexter Fowler walked with two outs in the third, and Denorfia drove him in with his first homer on the spring, off a 2-1 delivery from Cueto. They were the only Cubs runners to advance past first base.
"That was the plan, throwing four innings, and I felt great," said Cueto of his outing.
Ivan De Jesus Jr. had a ground-rule double for an RBI for the Reds' only run.
Devin Mesoraco, returning from a concussion, singled and walked in the game. Marlon Byrd, Brandon Phillips and Brennan Boesch also had hits for the Reds.
Up Next: Chicago hits the road again on Monday for a date with the Padres in Peoria. Jon Lester will get the start for the Cubs, and is expected to throw four innings. The newly-acquired left-hander has made two starts this spring, allowing five hits and zero runs over five innings of work. Neil Ramirez, Justin Grimm, Blake Parker, Jason Motte and Phil Coke are also expected to pitch against Brandon Morrow and the Padres. The game will be broadcast on Cubs.com.
Joey Nowak is a reporter for MLB.com. Follow him on Twitter at @joeynowak. This story was not subject to the approval of Major League Baseball or its clubs.