Right-hander Doug Fister started for the Nationals and went 2 1/3 innings, allowing two runs (one earned) on four hits. The Nats were behind, 2-0, before Fister left the game in the third inning. Errors by shortstop Ian Desmond and third baseman Kevin Frandsen allowed Jed Lowrie to score the first run of the game in the second inning. Springer led off the third and hit a home run over the right-field wall off Fister.
"Oh man, was that great to see or what?" Astros manager A.J. Hinch said of Springer. "He's been working real hard trying to get his timing right. You can't hold those two [homers]. It was good swings, good barrel contact like we like. Not many people can do what he did."
The Nationals then came back and scored three runs in the bottom of the third inning. Bryce Harper highlighted the scoring with a two-run double.
Houston then took a 4-3 lead by the top of the fifth inning. It was Springer who gave the Astros the lead with his second home run of the day, another solo shot over the right-field wall.
The Nationals scored two runs off right-hander Roberto Hernandez in the sixth inning to take a 6-5 lead. Kila Ka'aihue singled to right field, scoring Emmanuel Burriss. Cutter Dykstra then scored the fifth run of the game on a groundout by Rafael Bautista.
Ian Stewart added to Washington's lead in the bottom of the eighth inning by hitting a solo homer over the right-field wall off right-hander Josh Fields.
The Astros ended up tying the score in the top of the ninth off right-hander Scott McGregor. Jonathan Villar had an RBI single, while Jon Singleton had an RBI groundout.
Up next: Right-hander Collin McHugh will make his third start of the spring after two scoreless outings when the Astros travel to Lake Buena Vista, Fla., to meet the Braves at 5:05 p.m. CT on Saturday, live on Gameday Audio. McHugh led all Major League rookies with a 2.73 ERA last year and was named AL Rookie of the Month to cap a breakout season. Lefties Tony Sipp, Kevin Chapman and right-hander Chad Qualls are among those also scheduled to pitch.
Bill Ladson is a reporter for MLB.com and writes an MLBlog, All Nats All the Time. He also can be found on Twitter @WashingNats. This story was not subject to the approval of Major League Baseball or its clubs.