He is also set to play in Sunday's "B" game against the Pirates, which will last seven innings.
The 28-year-old backstop underwent Tommy John surgery last June and won't be the catcher in a Grapefruit League game until March 17.
Wieters is hitless in 20 at-bats with four strikeouts and a walk over six spring games. On Wednesday against the Blue Jays, he went 0-for-3 with a strikeout.
"We decided with him [that] with the at-bats yesterday, to take two days off to get his elbow [rest]," manager Buck Showalter said.
Christina DeNicola is a contributor to MLB.com This story was not subject to the approval of Major League Baseball or its clubs.