Jon Lester, making his second spring start, needed just six pitches to get through the first inning. The Cubs' Opening Night starter, Lester threw first-pitch strikes to 10 of the 11 batters he faced, and gave up three hits while striking out two over three innings.
"My tempo was good, which was good," Lester said of his outing. "[I got] quick outs, in the strike zone, which is obviously huge."
The Cubs players weren't fretting over their record, now are 1-6-1 in Cactus League play under Maddon, who was named the 54th manager in November.
"It is Spring Training, yes. Does it matter if we lost? No," first baseman Anthony Rizzo said. "We should be winning. It doesn't matter how you win or lose, you want to win at the end of the day. ... It's still super early."
The Cubs loaded the bases with one out in the second against Zack Greinke and the right-hander got Arismendy Alcantara to pop up, but then served up a two-run single to Mike Baxter. In his outing, Greinke gave up two hits, walked two and hit a batter.
Left-hander Julio Urias, 18, followed Greinke, and gave up consecutive singles to Rizzo, Starlin Castro and Miguel Montero to load the bases in the Chicago third. Chris Coghlan hit a sacrifice fly for a 3-0 lead, chasing Urias.
The Dodgers loaded the bases with one out in the fourth against Brian Schlitter and pulled within 3-2 on Justin Turner's two-run double. Another run scored when Joc Pederson grounded out, tying the game at 3.
Yasiel Puig robbed Rizzo of a possible extra-base hit with a running catch in right-center. Puig slammed into the wall, but ran off the field under his own power.
Phil Coke, who signed a Minor League deal with the Cubs, made his debut in the fifth and struck out one of four batters faced.
La Stella walked to lead off the Cubs' eighth and, after Valaika singled off of Chris Anderson, Chambers' hit a sacrifice fly to drive in the winning run.
Up next: Jason Hammel makes his second spring start Thursday when the Cubs travel to Tempe to face the Angels. In his first outing, against the Rockies, he gave up three runs on four hits, including a home run, and one walk. Last season, Hammel was 8-5 with a 2.98 ERA in 17 starts for the Cubs. Fans can listen to the game on an exclusive webcast on Cubs.com. First pitch is scheduled for 3:10 p.m. CT.