Federowicz suffered a tear to the lateral meniscus in his right knee in Sunday's game against the Rockies while playing defense, as he shifted from one side to another.
Federowicz, the front-runner to win the backup catching job, was having a strong camp. He had two hits in five at-bats and has been good, manager Bud Black said, with blocking balls defensively and working with the pitching staff.
The Padres still have six healthy catchers in camp. Derek Norris, who will be the starter, will get most of the reps moving forward. Wil Nieves figures to have the best shot of the catchers in camp to back up Norris as he has played parts of 11 big league seasons with seven teams.
Norris and Nieves are the only healthy catchers in camp with big league experience.
"We will continue to rotate those guys, but someone will have to pick up the innings we had planned for Tim," said Black. "Whether Wil gets all those ... it will be a combination of all those guys getting innings. Things haven't really changed for Wil as to how we'll use him."
Norris got the start Tuesday against the Giants in Peoria, marking the first time this spring he's started in consecutive games.
Corey Brock is a reporter for MLB.com. Keep track of @FollowThePadres on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.