Cano flew home to the Dominican Republic after learning of his grandfather's death on Saturday. The veteran has played in two Cactus League games this spring, going 2-for-5 with a double and two runs scored.
Willie Bloomquist, originally slated to play first base in Sunday's game against the Reds in Goodyear, instead will shift to second base to take Cano's spot and rookie D.J. Peterson will get the start at first base.
In other Sunday news from Mariners camp:
• Outfielder Franklin Gutierrez was taken out of Saturday's split-squad game in Glendale after three innings and will be sidelined for several days with tightness in his right groin muscle. Gutierrez is attempting to come back after sitting out all of 2014 to deal with health issues. He is 0-for-5 after his first two outings.
"That's to be expected," McClendon said of Gutierrez having soreness after playing back-to-back games. "He's been off almost two years. This is a grind down here. We'll give him a couple days off and try to get him back out there."
• Left-hander Danny Hultzen is scheduled to pitch an inning in relief on Wednesday against the Rockies in Peoria. It will be his first real game action since undergoing right shoulder surgery in 2013.
• The Mariners announced that Opening Day on April 6 against the Angels at Safeco Field is already a virtual sellout, with only some scattered single tickets remaining.
• Left-hander James Paxton threw a 40-pitch bullpen session and said he felt great as he continued building up after missing the first two weeks of camp with a bruised forearm. Paxton is on schedule for his first spring start on March 17.
Greg Johns is a reporter for MLB.com. Follow him on Twitter @GregJohnsMLB as well as his Mariners Musings blog. This story was not subject to the approval of Major League Baseball or its clubs.