Here are four things to look for:
1. Nats' newest ace: NYM@WAS
Scherzer takes the mound for the Nationals in their Grapefruit League opener in Viera, Fla. (5:05 p.m. ET on Gameday Audio), getting the starting nod over Stephen Strasburg. Both pitchers are on the same throwing schedule, but manager Matt Williams elected to go with Scherzer, who inked a seven-year, $210 million contract in the offseason. However, Williams said his decision is not necessarily indicative of his plans for Opening Day.
"There's nothing to read into it other than [Scherzer's] going to get the ball on Thursday, and five days later he'll get it again," Williams said.
2. Dodgers' star power: LAD@CWS
Kershaw, the defending National League Most Valuable Player and Cy Young Award winner, gets the ball for his Cactus League debut in a game that will be broadcast live on MLB.TV, MLB Network and Gameday Audio at 3:05 p.m. ET.
Yasiel Puig will start for the Dodgers in right field for his first action this spring, and A.J. Ellis will be behind the plate.
3. Throwback Thursday: OAK@CHC
Barry Zito continues his comeback attempt as he takes the mound against the Cubs in Mesa, Ariz., (3:05 p.m. ET). The left-hander will be pitching in an Oakland uniform for the first time since 2006. Zito is in camp on a Minor League deal, and the A's plan to give the veteran plenty of opportunities to earn a spot in their rotation.
"I have a fresh perspective," said Zito, who last pitched in September 2013 with the Giants. "I've got my passion back, and I just want to continue to work hard and go out and enjoy competing."
Fans can listen to an exclusive, free webcast on Athletics.com.
4. Ohio Cup: CLE@CIN
Coming off the Reds' first 20-win season since Danny Jackson in 1988, Johnny Cueto heads to the mound for the first time this spring in a game that will be broadcast live on MLB.TV, MLB Network and Gameday Audio at 3:05 p.m. ET. All-Star Michael Brantley is expected to be in the lineup for the Indians.