Tigers starter Anibal Sanchez went two scoreless innings and held the Orioles to just one hit, J.J. Hardy's one-out single in the first. Detroit also beat Baltimore, 15-2, on Tuesday.
In the top of the fifth, Dixon Machado singled and was caught in a rundown, with Anthony Gose crossing home plate to put the Tigers up a run. Nick Castellanos added a two-run homer off Chaz Roe after that.
The Orioles finally got on board with an RBI single from Dariel Alvarez in the bottom of the eighth inning. Alvarez would then score on Nolan Reimold's two-run hit.
Jayson Nix added a solo home run in the ninth.
Kevin Gausman started for the Orioles and pitched one scoreless inning, striking out J.D. Martinez on a 96-mph fastball.
"Given today and how I felt, I felt pretty good and pretty happy with it," Gausman said. "Getting the first one out of the way is always good."
Dylan Bundy would also make his spring debut, pitching a scoreless fourth inning.
Machado -- who is coming off his second consecutive season-ending knee surgery -- committed an error in his first play back, sailing a throw wide of first base to start the second inning. Machado rebounded with a nice backhanded play later in the game, making the grab in foul territory and throwing across the diamond to nab Hernan Perez.
"Manny needs to play in some games," manager Buck Showalter said. "You think about all the work he's done since he was able to go back on the field after the surgery. [Which is] the last time he really got to play a lot. [We want to] try to get as many reps for him as we can because physically it's not a challenge for him. He's in good shape."
Wieters, who will not be cleared to catch in games until March 17, served at designated hitter and went 0-for-3. Davis also went 0-for-3 while starting at first base.
Up next: Baltimore will play a split-squad contest, with Wei-Yin Chen starting the afternoon contest against the Rays in Port Charlotte, Fla, at 1:05 p.m. ET and Miguel Gonzalez pitching at night against the Blue Jays at Ed Smith Stadium at 7:05 p.m.
Brittany Ghiroli is a reporter for MLB.com. Read her blog, Britt's Bird Watch, and follow her on Facebook and Twitter @britt_ghiroli. This story was not subject to the approval of Major League Baseball or its clubs.