Saturday, the stakes won't be quite as high, but the atmosphere figures to be electric as the teams engage in the second game of a three-game Interleague series at Yankee Stadium on FOX's Saturday Game of the Week.
New York and Chicago met in a three-game set at Wrigley Field in June 2003, but for several members of the Cubs, this weekend marks a chance to visit one of the great, old stadiums in the Majors.
"It's one of the classic ballparks of all time, maybe the classic ballpark of all time," said Glendon Rusch, who will take the mound for the Cubs. "I look at that one, [Wrigley] and Fenway as just grounds that so many unbelievable players for so long a period of time have played in. They're classics."
Rusch lost his last start against the Red Sox, snapping a three-game winning streak in the process. The left-hander is 0-6 with a 7.16 ERA against the Yankees in his career, including an 0-3 mark and 5.63 ERA in the Bronx.
Despite his spotty history against the Yankees, Rusch, who took part in the Subway Series while pitching for the Mets in 2000 and '01, is looking forward to the matchup.
"I think it's exciting, especially a series like this," Rusch said. "I always look forward to going there. I loved it when I played there. I always enjoyed that city."
Taking the mound for the Yankees will be rookie right-hander Chien-Ming Wang, who will have gone eight days since his last start, the 8-1 loss to the Cardinals in St. Louis. Though Joe Torre called the loss one of the worst of his managing career, Wang was hardly to blame for his team's sloppy play.
"It was his worst game, but everything around him looked much worse than it was for him," said Torre, who isn't concerned about the extended rest for Wang. "The way he pitched with a great deal of rest before, I don't think it will be a problem."
Mark Feinsand is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.